Ashland Woman and Girl Seriously Injured in Three-Vehicle Crash on Highway 54 [Pike County, MO]

3 People Hospitalized After Crash on Highway 54 in Pike County

PIKE COUNTY, MO (April 23, 2026)— A woman and a teenage girl from Ashland suffered serious injuries Thursday in a three-vehicle crash on Highway 54 west of Route UU, according to the Missouri State Highway Patrol.

MSHP said all three vehicles were traveling eastbound when the driver of a semi-truck, a 35-year-old Jefferson City man, slowed for ducks in the roadway.

A 53-year-old Ashland woman driving a 2024 Nissan Rogue also slowed down. Moments later, a 2021 Isuzu NPR driven by a 53-year-old Edwardsville, Illinois, man struck the Nissan, according to the crash report.

The Ashland woman and her passenger, a 14-year-old girl from Ashland, sustained serious injuries. Emergency responders flew both victims to Barnes-Jewish Hospital in St. Louis for treatment.

The Edwardsville man suffered moderate injuries and was taken by ambulance to St. Joseph Hospital. The Jefferson City semi-truck driver reported no injuries.

Authorities said everyone involved in the crash wore seatbelts. The Missouri State Highway Patrol does not release the names of people involved in crashes.

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